Geldanamycin and its derivatives as Hsp90 inhibitors.

@article{Gorska2012GeldanamycinAI,
  title={Geldanamycin and its derivatives as Hsp90 inhibitors.},
  author={Magdalena Gorska and Urszula Popowska and Alicja Sielicka-Dudzin and Alicja Kuban-Jankowska and Wojciech Sawczuk and Narcyz Knap and Giuseppe Cicero and Fabio Wozniak},
  journal={Frontiers in bioscience},
  year={2012},
  volume={17},
  pages={
          2269-77
        }
}
The Hsp90 molecule, one of the most abundant heat shock proteins in mammalian cells, maintains homeostasis and prevents stress-induced cellular damage. Hsp90 is expressed under normal conditions at a level of about 1-2 Percent of total proteins, while its expression increases 2-10 fold in cancer cells. The two main constitutively expressed isoforms of Hsp90 are known as Hsp90-alpha and Hsp90-beta, and their upregulation is associated with tumor progression, invasion and formation of metastases… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 90 REFERENCES

Collins : Probing the Probes : Fitness Factors For Small Molecule Tools

J.
  • J Chem Biol
  • 2010

Combination Therapy of Bortezomib with Novel Targeted Agents: An Emerging Treatment Strategy

J. J. Wright
  • Clin Cancer Res 10, 1158-1078-0432
  • 2010
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