Geldanamycin and its anti-cancer activities.

@article{Fukuyo2010GeldanamycinAI,
  title={Geldanamycin and its anti-cancer activities.},
  author={Yayoi Fukuyo and Clayton R. Hunt and Nobuo Horikoshi},
  journal={Cancer letters},
  year={2010},
  volume={290 1},
  pages={
          24-35
        }
}
Geldanamycin is a benzoquinone ansamycin antibiotic that manifests anti-cancer activity through the inhibition of HSP90-chaperone function. The HSP90 molecular chaperone is expressed at high levels in a wide variety of human cancers including melanoma, leukemia, and cancers in colon, prostate, lung, and breast. In cancer cells dependent upon mutated and/or over-expressed oncogene proteins, HSP90 is thought to have a critical role in regulating the stability, folding, and activity of HSP90… CONTINUE READING
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