Gelation-driven component selection in the generation of constitutional dynamic hydrogels based on guanine-quartet formation

  title={Gelation-driven component selection in the generation of constitutional dynamic hydrogels based on guanine-quartet formation},
  author={Nampally Sreenivasachary and Jean‐Marie Lehn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={5938 - 5943}
  • N. Sreenivasachary, J. Lehn
  • Published 19 April 2005
  • Chemistry
  • Proceedings of the National Academy of Sciences of the United States of America
The guanosine hydrazide 1 yields a stable supramolecular hydrogel based on the formation of a guanine quartet (G-quartet) in presence of metal cations. The effect of various parameters (concentration, nature of metal ion, and temperature) on the properties of this gel has been studied. Proton NMR spectroscopy is shown to allow a molecular characterization of the gelation process. Hydrazide 1 and its assemblies can be reversibly decorated by acylhydrazone formation with various aldehydes… 

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