Gelastatins, New Inhibitors of Matrix Metalloproteinases from Westerdykella multispora F50733

  title={Gelastatins, New Inhibitors of Matrix Metalloproteinases from Westerdykella multispora F50733},
  author={H. J. Lee and M. Chung and C. Lee and H. Chun and J. Rhee and Y. Kho},
  journal={Annals of the New York Academy of Sciences},
Matrix metalloproteinases (MMPs) have been implicated in a variety of disease states, including rheumatoid arthritis, periodontal disease, tumor invasion, and metastasis. 1 In the MMP family, gelatinases (MMP-2 and MMP-9) are unique in their ability to cleave type IV collagen, a principal structural component of basement membrane, and have been focused on as pharmacological targets. Consequently specific inhibitors of gelatinases may be of value in the therapy of cancers as well as other… Expand

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