Gel-entrapment bioartificial liver therapy in galactosamine hepatitis.

@article{Sielaff1995GelentrapmentBL,
  title={Gel-entrapment bioartificial liver therapy in galactosamine hepatitis.},
  author={Timothy D. Sielaff and Mei Yu Hu and Bruce P. Amiot and Mark D. Rollins and Krs Sambasiva Rao and Brendan S. McGuire and JosephR. Bloomer and Wei Shou Hu and Frank B. Cerra},
  journal={The Journal of surgical research},
  year={1995},
  volume={59 1},
  pages={
          179-84
        }
}
A need exists for an effective, safe bioartificial liver to support patients in fulminant hepatic failure (FHF). The purpose of this study was to determine the treatment efficacy of the novel gel-entrapment porcine hepatocyte bioartificial liver (BAL) in a fatal model of canine hepatic failure. FHF was produced in 27- to 30-kg halothane-anesthetized dogs by bolus infusion of the hepatotoxin D-galactosamine (D-Gal). Three groups were studied during the 48-hr experiment: Group D-Gal (n = 5… CONTINUE READING
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