Gel-based proteomics in disease research: Is it still valuable?

  title={Gel-based proteomics in disease research: Is it still valuable?},
  author={Yong-In Kim and Je-Yoel Cho},
  journal={Biochimica et biophysica acta. Proteins and proteomics},
  volume={1867 1},
Gel electrophoresis had been the primary method in proteomics. In the early era of proteomics, gel electrophoresis was a dominant technique of sample preparation for mass spectrometry analysis. Particularly, two-dimensional electrophoresis provided high-resolution proteome separation, and was regarded as the standard methodology for the separation of wide-range proteomes. However, gel electrophoresis turned downwards due to the progress of other separations including liquid chromatography and… CONTINUE READING
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