Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan.

@article{Nishi2012GeissoschizineME,
  title={Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan.},
  author={Akinori Nishi and Taku Yamaguchi and Kyoji Sekiguchi and Shinichi Imamura and Masahiro Tabuchi and Hitomi Kanno and Yukihito Nakai and Katsunori Hashimoto and Yasushi Ikarashi and Yoshio Kase},
  journal={Neuroscience},
  year={2012},
  volume={207},
  pages={124-36}
}
Yokukansan (YKS), a traditional Japanese medicine, is composed of seven kinds of dried herbs. It is widely prescribed in clinical situation for treating psychiatric disorders such as aggressiveness in patients with dementia. We previously demonstrated that YKS and Uncaria hook (UH), which is a constituent herb of YKS, had a partial agonistic effect to 5-HT(1A) receptors in vitro. However, it has still been unclear whether this in vitro effect is reflected in in vivo, and what the active… CONTINUE READING
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