Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells

@inproceedings{Shi2014GefitinibLF,
  title={Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells},
  author={Yijie Shi and Chang Su and Wenyu Cui and Hongdan Li and Liwei Liu and Bo Feng and Ming Liu and Rong-jian Su and Liang Zhao},
  booktitle={Journal of nanobiotechnology},
  year={2014}
}
BACKGROUND Active targeting endocytosis mediated by the specific interaction between folic acid and its receptor has been a hotspot in biological therapy of many human cancers. Various studies have demonstrated that folate and its conjugates could facilitate the chemotherapeutic drug delivery into folate receptor (FR)-positive tumor cells in vitro and in vivo. In order to utilize FA-FR binding specificity to achieve targeted delivery of drugs into tumor cells, we prepared Gefitinib loaded… CONTINUE READING