Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial.

@article{Dutton2014GefitinibFO,
  title={Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial.},
  author={Susan J Dutton and David Raymond Ferry and Jane M. Blazeby and Haider Abbas and Asa Dahle-Smith and Wasat Mansoor and Joyce Thompson and Mark S. Harrison and Anirban Chatterjee and Stephen J. Falk and Angel Garcia-Alonso and David Walter Fyfe and Richard A. Hubner and Tina Gamble and Lynnda Peachey and Mina Davoudianfar and Sarah R Pearson and Patrick Julier and Janusz Jankowski and Rachel S Kerr and Russell David Petty},
  journal={The Lancet. Oncology},
  year={2014},
  volume={15 8},
  pages={894-904}
}
BACKGROUND Evidence is scarce for the effectiveness of therapies for oesophageal cancer progressing after chemotherapy, and no randomised trials have been reported. We aimed to compare gefitinib with placebo in previously treated advanced oesophageal cancer. METHODS For this phase 3, parallel, randomised, placebo-controlled trial, eligible patients were adults with advanced oesophageal cancer or type I/II Siewert junctional tumours, histologically confirmed squamous-cell carcinoma or… CONTINUE READING

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