Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation.

@article{Ferraris2012GeduninAN,
  title={Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation.},
  author={Fausto K. Ferraris and Katelim Hottz Moret and Alexandre Bezerra Conde Figueiredo and Carmen Penido and Maria G Henriques},
  journal={International immunopharmacology},
  year={2012},
  volume={14 1},
  pages={82-93}
}
T lymphocytes are critical cells involved in allergy. Here, we report that the natural tetranortriterpenoid gedunin impaired allergic responses primarily by modulating T lymphocyte functions. The intraperitoneal (i.p.) administration of gedunin inhibited pleural leukocyte accumulation triggered by intra-pleural (i.pl.) challenge with ovalbumin (OVA) in… CONTINUE READING