Gd-containing conjugated polymer nanoparticles: bimodal nanoparticles for fluorescence and MRI imaging.

  title={Gd-containing conjugated polymer nanoparticles: bimodal nanoparticles for fluorescence and MRI imaging.},
  author={Zeina Hashim and Mark Green and Pei Hua Chung and Klaus Suhling and Andrea Protti and Alkystsis Phinikaridou and Ren{\'e} Botnar and Raha Ahmad Khanbeigi and Maya Thanou and Lea Ann Dailey and Nicola J. Commander and C. S. Rowland and Jo Scott and Dominic C. Jenner},
  volume={6 14},
Aqueous bifunctional semiconductor polymer nanoparticles (SPNs), approximately 30 nm in diameter (as measured from electron microscopy), were synthesised using hydrophobic conjugated polymers, amphiphilic phospholipids and a gadolinium-containing lipid. Their fluorescence quantum yields and extinction coefficients were determined, and their MRI T₁-weighted relaxation times in water were measured. The bimodal nanoparticles were readily taken up by HeLa and murine macrophage-like J774 cells as… CONTINUE READING
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