Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.

@article{Goswami2012Gcn5IR,
  title={Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.},
  author={Ritobrata Goswami and Mark H Kaplan},
  journal={Journal of immunology},
  year={2012},
  volume={189 6},
  pages={
          3026-33
        }
}
Naive CD4+ T cells differentiate into various effector Th subsets depending on the Ags and cytokine microenvironment they encounter. IL-9-secreting Th9 cells are the most recent Th subset to be described. PU.1, one of the transcription factors required for the development of Th9 cells, binds to the Il9 gene. In this study, we show that PU.1 increases histone acetylation at the Il9 locus through direct interactions with histone acetyltransferases. In the absence of PU.1, there is decreased… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS, ESTIMATED 54% COVERAGE

63 Citations

051015'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 63 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…