Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia.

@article{Liu2007Gcm2IR,
  title={Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia.},
  author={Zhijie Liu and Shannon F. Yu and Nancy R Manley},
  journal={Developmental biology},
  year={2007},
  volume={305 1},
  pages={333-46}
}
The parathyroid glands develop with the thymus from bilateral common primordia that develop from the 3rd pharyngeal pouch endoderm in mouse embryos at about E11, each of which separates into one parathyroid gland and one thymus lobe by E13.5. Gcm2, a mouse ortholog of the Drosophila Glial Cells Missing gene, is expressed in the parathyroid-specific domains in the 3rd pouches from E9.5. The null mutation of Gcm2 causes aparathyroidism in the fetal and adult mouse and has been proposed to be a… CONTINUE READING

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