Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor.

@article{Gressner2008GcglobulinD,
  title={Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor.},
  author={Olav Axel Gressner and Birgit Lahme and Axel M. Gressner},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2008},
  volume={390 1-2},
  pages={
          28-37
        }
}
BACKGROUND Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation. The present study was performed to analyze the interaction between gc-globulin of hepatocytes and hepatic stellate cells, the most important fat-/retinol-storing cell type in the liver, which spontaneously transdifferentiates to myofibroblasts in culture. METHODS Hepatic stellate cells… CONTINUE READING

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