GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

@article{Kim2003GbetaLAP,
  title={GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.},
  author={Do-Hyung Kim and Dos D. Sarbassov and S. Machmud Ali and Robert R. Latek and Kalyani V.P. Guntur and Hediye Erdjument-Bromage and Paul Tempst and David M. Sabatini},
  journal={Molecular cell},
  year={2003},
  volume={11 4},
  pages={895-904}
}
mTOR and raptor are components of a signaling pathway that regulates mammalian cell growth in response to nutrients and growth factors. Here, we identify a member of this pathway, a protein named GbetaL that binds to the kinase domain of mTOR and stabilizes the interaction of raptor with mTOR. Like mTOR and raptor, GbetaL participates in nutrient- and growth factor-mediated signaling to S6K1, a downstream effector of mTOR, and in the control of cell size. The binding of GbetaL to mTOR strongly… CONTINUE READING
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References

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interacts with raptor to form a nutrient-sensitive complet

  • T. F. Smith, C. Gaitatzes, K. Saxena, E. J. Neer
  • 1999
Highly Influential
4 Excerpts

myc- and HA-prk5, and confirmed by DNA sequencing. The G L mutants used in this study are S72D, G192D, and F320S

  • P. E. Burnett, R. K. Barrow, N. A. Cohen, S. H. Snyder, Sabatini
  • Proc. Natl. Acad. Sci. USA
  • 1998
Highly Influential
6 Excerpts

IdentiDC1). All other epitope tagged constructs have been described fication of an 11-kDa FKBP12-rapamycin-binding domain within the (Burnett et

  • J. Chen, X. F. Zheng, E. J. Brown, S. L. Schreiber
  • 1995
Highly Influential
4 Excerpts

Regulation of cell size in Biochem

  • S. C. Kozma, G. Thomas
  • 2002
Highly Influential
3 Excerpts

A mouse model Higgins, D.G

  • M. gauer, N. el-Hashemite, H. Onda
  • 2002

Regulation of cell size in

  • S. C. TrendsKozma, G. Thomas
  • Biochem . Sci .
  • 2002

mTOR cells

  • H. ment-Bromage, P. Tempst, D. M. Sabatini
  • Cancer Res
  • 2002

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