Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.

@article{Wong2017GavageOF,
  title={Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.},
  author={Sunny Hei Wong and Liuyang Zhao and Xiang Zhang and Geicho Nakatsu and Juqiang Han and Weiqi Xu and Xue Xiao and Thomas N. Y. Kwong and Ho Leung Tsoi and William Wu and Benhua Zeng and Francis K L Chan and Joseph Jy Y. Sung and Hong He Wei and Jun Yu},
  journal={Gastroenterology},
  year={2017},
  volume={153 6},
  pages={
          1621-1633.e6
        }
}
BACKGROUND & AIMS Altered gut microbiota is implicated in development of colorectal cancer (CRC). Some intestinal bacteria have been reported to potentiate intestinal carcinogenesis by producing genotoxins, altering the immune response and intestinal microenvironment, and activating oncogenic signaling pathways. We investigated whether stool from patients with CRC could directly induce colorectal carcinogenesis in mice. METHODS We obtained stored stool samples from participants in a… CONTINUE READING
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Gut mucosal microbiome across stages of co l rectal carcinogenesis

  • G Nakatsu, X Li, H Zhou
  • 2015

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