Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

@inproceedings{Krumsiek2010GaussianGM,
  title={Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data},
  author={Jan Krumsiek and Karsten Suhre and Thomas Illig and Jerzy Adamski and Fabian J. Theis},
  booktitle={BMC Systems Biology},
  year={2010}
}
With the advent of high-throughput targeted metabolic profiling techniques, the question of how to interpret and analyze the resulting vast amount of data becomes more and more important. In this work we address the reconstruction of metabolic reactions from cross-sectional metabolomics data, that is without the requirement for time-resolved measurements or specific system perturbations. Previous studies in this area mainly focused on Pearson correlation coefficients, which however are… CONTINUE READING
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