Gaussian Process Models of Dynamic PET for Functional Volume Definition in Radiation Oncology

@article{Shepherd2012GaussianPM,
  title={Gaussian Process Models of Dynamic PET for Functional Volume Definition in Radiation Oncology},
  author={Tony Shepherd and Rikard Owenius},
  journal={IEEE Transactions on Medical Imaging},
  year={2012},
  volume={31},
  pages={1542-1556}
}
In routine oncologic positron emission tomography (PET), dynamic information is discarded by time-averaging the signal to produce static images of the “standardised uptake value” (SUV). Defining functional volumes of interest (VOIs) in terms of SUV is flawed, as values are affected by confounding factors and the chosen time window, and SUV images are not sensitive to functional heterogeneity of pathological tissues. Also, SUV iso-contours are highly affected by the choice of threshold and no… CONTINUE READING

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