Gauging recovery after hemorrhagic stroke in rats: implications for cytoprotection studies.

@article{Maclellan2006GaugingRA,
  title={Gauging recovery after hemorrhagic stroke in rats: implications for cytoprotection studies.},
  author={Crystal L Maclellan and Angela Michelle Auriat and Steven C. McGie and Reginia H. Y. Yan and Hang D Huynh and Maxine F De Butte and Frederick Colbourne},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2006},
  volume={26 8},
  pages={
          1031-42
        }
}
Successful clinical translation of prospective cytoprotectants will likely occur only with treatments that improve functional recovery in preclinical (rodent) studies. Despite this assumption, many rely solely on histopathologic end points or the use of one or two simple behavioral tests. Presently, we used a battery of tests to gauge recovery after a unilateral intracerebral hemorrhagic stroke (ICH) targeting the striatum. In total, 60 rats (N=15 per group) were stereotaxically infused with 0… CONTINUE READING
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