Gaucher-like changes in human blood-derived macrophages induced by beta-glucocerebrosidase inhibition.

@article{Yatziv1988GaucherlikeCI,
  title={Gaucher-like changes in human blood-derived macrophages induced by beta-glucocerebrosidase inhibition.},
  author={Shaul Yatziv and David S Newburg and Nelly Livni and G Barfi and Edwin H. Kolodny},
  journal={The Journal of laboratory and clinical medicine},
  year={1988},
  volume={111 4},
  pages={416-20}
}
Human blood-derived macrophages were cultured in the presence of conduritol-B-epoxide, a specific inhibitor of beta-glucosidase, to induce changes resembling those occurring in the cells of patients with Gaucher's disease. After 24 hours of incubation, only 5% of the original beta-glucosidase activity remained; on removal of the inhibitor, the enzyme activity recovered almost fully to control levels after 5 days. After 30 days of incubation with conduritol-B-epoxide, the macrophages contained… CONTINUE READING

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