Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.

@article{Capes2012GatingTI,
  title={Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.},
  author={Deborah L. Capes and Manoel Arcisio-Miranda and Brian W. Jarecki and Robert J. French and Baron Chanda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 7},
  pages={2648-53}
}
Voltage-dependent ion channels are crucial for generation and propagation of electrical activity in biological systems. The primary mechanism for voltage transduction in these proteins involves the movement of a voltage-sensing domain (D), which opens a gate located on the cytoplasmic side. A distinct conformational change in the selectivity filter near the extracellular side has been implicated in slow inactivation gating, which is important for spike frequency adaptation in neural circuits… CONTINUE READING
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