Gating the selectivity filter in ClC chloride channels.

@article{Dutzler2003GatingTS,
  title={Gating the selectivity filter in ClC chloride channels.},
  author={Raimund Dutzler and Ernest B. Campbell and Roderick MacKinnon},
  journal={Science},
  year={2003},
  volume={300 5616},
  pages={108-12}
}
ClC channels conduct chloride (Cl-) ions across cell membranes and thereby govern the electrical activity of muscle cells and certain neurons, the transport of fluid and electrolytes across epithelia, and the acidification of intracellular vesicles. The structural basis of ClC channel gating was studied. Crystal structures of wild-type and mutant… CONTINUE READING