Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo.

@article{Samovski2010GatingOT,
  title={Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo.},
  author={Dmitri Samovski and Bella Kalderon and Einav Yehuda-Shnaidman and Jacob Bar-Tana},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 10},
  pages={6879-90}
}
The role played by long chain fatty acids (LCFA) in promoting energy expenditure is confounded by their dual function as substrates for oxidation and as putative classic uncouplers of mitochondrial oxidative phosphorylation. LCFA analogs of the MEDICA (MEthyl-substituted DICarboxylic Acids) series are neither esterified into lipids nor beta-oxidized and may thus simulate the uncoupling activity of natural LCFA in vivo, independently of their substrate role. Treatment of rats or cell lines with… CONTINUE READING
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