Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels by Adenosine Triphosphate Hydrolysis

@article{Zeltwanger1999GatingOC,
  title={Gating of Cystic Fibrosis Transmembrane Conductance Regulator  Chloride Channels by Adenosine Triphosphate Hydrolysis  },
  author={Shawn Zeltwanger and Fei Wang and Guo-Tang Wang and Kevin D. Gillis and Tzyh-Chang Hwang},
  journal={The Journal of General Physiology},
  year={1999},
  volume={113},
  pages={541 - 554}
}
Gating of the cystic fibrosis transmembrane conductance regulator (CFTR) involves a coordinated action of ATP on two nucleotide binding domains (NBD1 and NBD2). Previous studies using nonhydrolyzable ATP analogues and NBD mutant CFTR have suggested that nucleotide hydrolysis at NBD1 is required for opening of the channel, while hydrolysis of nucleotides at NBD2 controls channel closing. We studied ATP-dependent gating of CFTR in excised inside-out patches from stably transfected NIH3T3 cells… CONTINUE READING
47 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Regulation of gating of CFTR Cl channels by phosphorylation and ATP hydrolysis

  • T C Hwang, G Nagel, A C Narin, D C Gadsby
  • Proc. Natl. Acad. Sci. USA. 91
  • 1994
Highly Influential
20 Excerpts

A Q-matrix cookbook

  • D Colquhoun, A G Hawkes
  • A Q-matrix cookbook
  • 1995
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…