Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels.

@article{LiSmerin1998GatingMT,
  title={Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels.},
  author={Yingying Li-Smerin and Kenton Jon Swartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 15},
  pages={8585-9}
}
Protein toxins from venomous animals exhibit remarkably specific and selective interactions with a wide variety of ion channels. Hanatoxin and grammotoxin are two related protein toxins found in the venom of the Chilean Rose Tarantula, Phrixotrichus spatulata. Hanatoxin inhibits voltage-gated K+ channels and grammotoxin inhibits voltage-gated Ca2+ channels. Both toxins inhibit their respective channels by interfering with normal operation of the voltage-dependent gating mechanism. The sequence… CONTINUE READING

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