Gating mechanisms of canonical transient receptor potential channel proteins: role of phosphoinositols and diacylglycerol.

@article{Albert2011GatingMO,
  title={Gating mechanisms of canonical transient receptor potential channel proteins: role of phosphoinositols and diacylglycerol.},
  author={Anthony P Albert},
  journal={Advances in experimental medicine and biology},
  year={2011},
  volume={704},
  pages={391-411}
}
Canonical transient receptor potential (TRPC) Ca(2+)-permeable channels are members of the mammalian TRP super-family of cation channels, and have the closest homology to the founding members, TRP and TRPL, discovered in Drosophila photoreceptors. The TRPC subfamily is composed of 7 subunits (C1-C7, with TRPC2 a pseudogene in humans), which can all combine with one another to form homomeric and heteromeric structures. This review focuses on mechanisms involved in opening TRPC channels (i.e… CONTINUE READING

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