Gating-dependent mechanism of 4-aminopyridine block in two related potassium channels.

Abstract

4-aminopyridine (4AP) is widely used as a selective blocker of voltage-activated K+ currents in excitable membranes, but its mechanism and site of action at the molecular level are not well understood. To address this problem we have analyzed 4AP block in Kv2.1 and Kv3.1, mammalian representatives of the Drosophila Shab and Shaw subfamilies of voltage-gated… (More)

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@article{Kirsch1993GatingdependentMO, title={Gating-dependent mechanism of 4-aminopyridine block in two related potassium channels.}, author={Glenn E. Kirsch and John A Drewe}, journal={The Journal of general physiology}, year={1993}, volume={102 5}, pages={797-816} }