Gating and regulation of connexin 43 (Cx43) hemichannels.

@article{Contreras2003GatingAR,
  title={Gating and regulation of connexin 43 (Cx43) hemichannels.},
  author={Jorge E Contreras and Juan C S{\'a}ez and Feliksas F. Bukauskas and Michael V. L. Bennett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 20},
  pages={
          11388-93
        }
}
Connexin 43 (Cx43) nonjunctional or "unapposed" hemichannels can open under physiological or pathological conditions. We characterize hemichannels comprised of Cx43 or Cx43-EGFP (Cx43 with enhanced GFP fused to the C terminus) expressed in HeLa cells. Channel opening was induced at potentials greater than +60 mV. Open probability appeared to be very low. No comparable opening was detected in the parental, nontransfected HeLa cells. Conductance of fully open single hemichannels was approximately… CONTINUE READING

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