Gating-Related Molecular Motions in the Extracellular Domain of the IKs Channel: Implications for IKs Channelopathy

@article{Wang2010GatingRelatedMM,
  title={Gating-Related Molecular Motions in the Extracellular Domain of the IKs Channel: Implications for IKs Channelopathy},
  author={Yu Hong Wang and Min Jiang and Xu Xu and Kai-Ling Hsu and Mei Zhang and G. H. Tseng},
  journal={The Journal of Membrane Biology},
  year={2010},
  volume={239},
  pages={137-156}
}
Cardiac slow delayed rectifier (IKs) channel complex consists of KCNQ1 channel and KCNE1 auxiliary subunits. The extracellular juxtamembranous region of KCNE1 is an unstructured loop that contacts multiple KCNQ1 positions in a gating-state-dependent manner. Congenital arrhythmia-related mutations have been identified in the extracellular S1–S2 linker of… CONTINUE READING