Gateways to clinical trials.

  title={Gateways to clinical trials.},
  author={A Tomillero and M. A. Moral},
  journal={Methods and findings in experimental and clinical pharmacology},
  volume={32 6},
  • A. Tomillero, M. A. Moral
  • Published 1 July 2010
  • Medicine
  • Methods and findings in experimental and clinical pharmacology
A-3309, Abobotulinumtoxin A, Adalimumab, AIDSVAX gp120 B/E, ALVAC E120TMG, Atorvastatin calcium; Bepridil, Bevacizumab; Candesartan cilexetil, Capecitabine, Cetuximab, Clopidogrel; Dapagliflozin, Dasatinib, Denosumab, Dexmedetomidine hydrochloride, Diacetylmorphine, Diannexin, Docetaxel, Dutasteride; Entecavir, Eplerenone, Erlotinib hydrochloride, Escitalopram oxalate, Everolimus, Ezetimibe; Fesoterodine fumarate, Flagellin.HuM2e, Fluzone; Glimepiride/rosiglitazone maleate; Hyaluronic acid… Expand
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
This paper is a comprehensive overview of the scientific efforts made to develop novel antileukemia therapeutics by presenting chemical, pharmacological, and pharmacogenomic data obtained during preclinical and clinical assessment of these agents. Expand
Tapentadol, una nueva opción terapéutica
Recientemente se ha introducido in el mercado el tapentadol, que combina en una misma molecula acciones de ambos mecanismos de accion, lo cual supone una novedosa, mejorada and eficiente alternativa a the terapia analgesica. Expand
Mitochondrial gateways to cancer.
Several mechanisms by which mitochondria can contribute to malignant transformation and tumor progression are discussed. Expand
Cancer Immunotherapy Confers a Global Benefit
Cancer immunotherapy confers a global benefit and everybody all around the world has the right to benefit from this novel therapeutic avenue, which prevents further disabilities due to cancer progression or therapies and improves quality of life of patients. Expand
Prolonged Urocortin 2 Administration in Experimental Heart Failure: Sustained Hemodynamic, Endocrine, and Renal Effects
4-day urocortin 2 administration induces sustained improvements in hemodynamics and renal function, in association with inhibition of multiple vasoconstrictor/volume-retaining systems, and these findings support the therapeutic potential for uroc Cortin 2 in heart failure. Expand
Interleukin-6 signaling pathway in targeted therapy for cancer.
The progress of the current understanding of IL-6 signaling pathway in cancer as well as an antibody targeted IL- 6 therapy for human cancer are detailed. Expand
Radiation, Inflammation, and Immune Responses in Cancer
Since inflammation and sex steroids also impact tumorigenesis, a therapeutic approach targeting glucocorticoid receptors and radiation-induced production of tumorigenic factors might be effective in sensitizing certain tumors to IR. Expand
NOD-like receptors and inflammation
The role played by NLRs in a variety of inflammatory diseases is discussed and the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function is described. Expand
Contrast Ultrasound in Imaging Tumor Angiogenesis
It is concluded that targeted MB represent a novel and attractive tool for non-invasive, vascular-targeted molecular imaging of tumor angiogenesis and for monitoring vascular effects specific to anti-tumor therapy in vivo. Expand
CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats.
It can be concluded that uterine expression of the analyzed retinoid-response genes during early gestation is not altered by this R115866 treatment and instead indirectly via ATRA, which cannot confirm that ATRA obtains a major influencing role in the regulation of embryonic implantation. Expand