Gates and filters: unveiling the physiological roles of nicotinic acetylcholine receptors in dopaminergic transmission.

@article{Wonnacott2008GatesAF,
  title={Gates and filters: unveiling the physiological roles of nicotinic acetylcholine receptors in dopaminergic transmission.},
  author={Susan Wonnacott},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 Suppl 1},
  pages={S2-4}
}
Neuronal nicotinic acetylcholine receptors (nAChRs) in the brain have been enigmatic players on the cerebral stage. As ligand-gated ion channels they were expected to mediate fast cholinergic transmission, yet their influence appears to be modulatory. Two reviews in this issue of the BJP consider the relationship between nAChRs and endogenous ACh, with respect to the modulation of dopaminergic signalling. In his review, Maskos posits that in midbrain dopamine neurons, somatodendritic nAChRs… CONTINUE READING