Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

  title={Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation},
  author={Marie-Liesse Asselin-Labat and Kate D Sutherland and Holly V. Barker and Richard Thomas and Mark Shackleton and Natasha C. Forrest and Lynne Hartley and Lorraine Robb and Frank G. Grosveld and Jacqueline van der Wees and Geoffrey J Lindeman and Jane E. Visvader},
  journal={Nature Cell Biology},
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epithelial development and oncogenesis, we have explored its normal function within the mammary gland by conditionally deleting Gata-3 at different stages of development. We report that Gata-3 has essential roles in the morphogenesis of the mammary gland in both the embryo and adult. Through the discovery of a novel marker (β3-integrin) of luminal… CONTINUE READING
Highly Influential
This paper has highly influenced 39 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 371 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

Generation of a functional mammary gland from a single stem cell

  • M Shackleton
  • Nature 439,
  • 2006

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development

  • Sum, Y E.
  • Oncogene 24,
  • 2005

Similar Papers

Loading similar papers…