Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

@article{AsselinLabat2007Gata3IA,
  title={Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation},
  author={Marie-Liesse Asselin-Labat and Kate D Sutherland and Holly V. Barker and Richard Thomas and Mark Shackleton and Natasha C. Forrest and Lynne Hartley and Lorraine Robb and Frank G. Grosveld and Jacqueline van der Wees and Geoffrey J Lindeman and Jane E. Visvader},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={201-209}
}
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epithelial development and oncogenesis, we have explored its normal function within the mammary gland by conditionally deleting Gata-3 at different stages of development. We report that Gata-3 has essential roles in the morphogenesis of the mammary gland in both the embryo and adult. Through the discovery of a novel marker (β3-integrin) of luminal… CONTINUE READING
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