Gat1 (Gaba:Na+:Cl−) Cotransport Function

  title={Gat1 (Gaba:Na+:Cl−) Cotransport Function},
  author={C C Lu and Donald W Hilgemann},
  journal={The Journal of General Physiology},
  pages={445 - 458}
To explain cotransport function, the "alternating access" model requires that conformational changes of the empty transporter allow substrates to bind alternatively on opposite membrane sides. To test this principle for the GAT1 (GABA:Na+:Cl-) cotransporter, we have analyzed how its charge-moving partial reactions depend on substrates on both membrane sides in giant Xenopus oocyte membrane patches. (a) "Slow" charge movements, which require extracellular Na+ and probably reflect occlusion of Na… CONTINUE READING
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