Gastroschisis and associated defects: an international study.


Our objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.

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@article{Mastroiacovo2007GastroschisisAA, title={Gastroschisis and associated defects: an international study.}, author={Pierpaolo Mastroiacovo and Alessandra Lisi and Eduardo Enrique Castilla and Mar{\'i}a-Luisa Mart{\'i}nez-Fr{\'i}as and Eva Bermejo and Lisa K. Marengo and Jim Kucik and Csaba Siffel and Jane Lavinia Halliday and Miriam Gatt and G{\"{o}ran Ann{\'e}ren and Fabrizio Bianchi and Marco Canessa and Ron Danderfer and Hermien E. K. de Walle and John Alexander Harris and Zhu Li and Robert Brian Lowry and Robert McDonell and Paul L Merlob and J{\'u}lia M{\'e}tneki and Osvaldo M. Mutchinick and Elisabeth Robert-Gnansia and Gioacchino Scarano and Anton{\'i}n {\vS}{\'i}pek and Simone Poetzsch and Elena Szabov{\'a} and Lyubov Yevtushok}, journal={American journal of medical genetics. Part A}, year={2007}, volume={143A 7}, pages={660-71} }