Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E₂.

@article{Rozza2011GastroprotectiveMO,
  title={Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E₂.},
  author={Ariane Leite Rozza and Thiago de Mello Moraes and H{\'e}lio Kushima and Alexandre Tanimoto and M{\'a}rcia Ortiz Mayo Marques and Tais M Bauab and Cl{\'e}lia Akiko Hiruma-Lima and Cl{\'a}udia Helena Pellizzon},
  journal={Chemico-biological interactions},
  year={2011},
  volume={189 1-2},
  pages={
          82-9
        }
}
Citrus lemon (CL) belongs to Rutaceae family and is popularly known in Brazil as limão siciliano. The phytochemical analysis of CL fruit bark essential oil showed two majority components, limonene (LIM) and β-pinene (PIN). This study aimed to evaluate the gastroprotective mechanism of action from CL, LIM and PIN in ethanol- and indomethacin-induced gastric ulcers and its in vitro anti-Helicobacter pylori activity. After ethanol-induced gastric ulcer, the ulcer area was measured and the stomachs… CONTINUE READING

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