Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression.

  title={Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression.},
  author={Matheus Chiaradia de Souza and Ana J{\'u}lia Vieira and Fernando Pereira Beserra and Cl{\'a}udia Helena Pellizzon and Rafael Henrique N{\'o}brega and Ariane Leite Rozza},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},

Investigation of the Gastroprotective Effect of Betaine-Homocysteine Homeostasis on Oxidative Stress, Inflammation and Apoptosis in Ethanol-Induced Ulcer Model

It is illustrated that betaine exhibits a gastroprotective effect against ulcers through the homocysteine pathway by modulating oxidative stress in the gastric tissue; however, its systemic effects should not be ignored.

Protective effects of scutellarin on acute alcohol gastric injury

The data suggest that SCU may be an attractive therapeutic strategy to mitigate the development of gastric tissue injury and enhances the gastric response to oxidative stress and effectively reduces the inflammatory response.

Anti-Inflammatory Effect of Vanillin Protects the Stomach against Ulcer Formation

The gastroprotective activity of vanillin is related to the maintenance of gastric mucus and the local inflammatory response modulation, which was linked to anti-inflammatory activity as a result of decreasing the levels of TNF-α, IL-6,IL-1β, and IFN-γ and increasing IL-10 levels.

Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis

It is revealed that MFA had significant gastroprotective effects against ethanol-induced gastric injuries and could be a promising adjuvant therapy for ulcer treatment.

Anti-Inflammation and Protective Effects of Anethum graveolens L. (Dill Seeds) on Esophageal Mucosa Damages in Reflux Esophagitis-Induced Rats

AGS have good physiological activity and the possibility of being used as a medicinal food and a functional resource for the prevention and therapy of gastroesophageal diseases.

Commiphora myrrh Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats

Myrrh enables gastric mucosa to counteract the ethanol’s inflammatory and apoptotic processes leading to improved gastric proliferation and healing, and Interestingly, myrrh extract showed better protective and curative effects thanmyrrh oil against gastric ulceration.

Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats

Paeonol and its stable sustained-release tablet GRT-Ps can promote ulcer healing by inhibiting oxidative stress and regulating the intestinal flora and improve the richness and diversity of theestinal flora and increase the amount of beneficial bacteria, such as Lactobacillus.

Protective effects of total flavonoids from Alpinia officinarum rhizoma against ethanol-induced gastric ulcer in vivo and in vitro

F-AOH inhibits ethanol-induced gastric mucosal damage, provides a theoretical basis for galangal in the treatment of other causes of GU, and promotes the application of galanga in thetreatment of GU.



Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms.

The protective activity of TRG against indomethacin-induced gastric ulcer has been ascribed to three important mechanisms: anti-inflammatory; (2) antioxidant; (3) anti-apoptotic pathways.

Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats

Pre-treatment with cimetidine or Pu-erh tea extracts markedly suppressed the formation of ethanol-induced gastric lesions and clear decreases in MPO activity and ADMA concentration in the gastric mucosal homogenate were observed following pretreatment.

Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats

Significant increased in the pH, mucus of gastric content and high levels of PGE2, SOD and reduced amount of MDA was observed and the plant promotes ulcer protection as it shows significant reduction of ulcer area grossly.

Anti-Inflammatory and Gastroprotective Roles of Rabdosia inflexa through Downregulation of Pro-Inflammatory Cytokines and MAPK/NF-κB Signaling Pathways

Experimental findings suggested that the anti-inflammatory and gastroprotective activities of RI might contribute to regulating pro-inflammatory cytokines and MAPK/NF-κB signaling pathways.