Gastroprotective effect of heme-oxygenase 1/biliverdin/CO pathway in ethanol-induced gastric damage in mice.

@article{Gomes2010GastroprotectiveEO,
  title={Gastroprotective effect of heme-oxygenase 1/biliverdin/CO pathway in ethanol-induced gastric damage in mice.},
  author={Antoniella Souza Gomes and Gemima G Gadelha and Samara J Lima and J. Alves Garcia and Jand Venes R Medeiros and Alexandre Havt and Aldo {\^A}ngelo M Lima and Ronaldo de Albuquerque Ribeiro and Gerly Anne Casto Brito and Fernando Q Cunha and Marcellus Henrique Loiola Ponte de Souza},
  journal={European journal of pharmacology},
  year={2010},
  volume={642 1-3},
  pages={140-5}
}
Our objective was to evaluate the role of heme-oxygenase 1 (HO-1)/biliverdin/CO pathway in gastric defense against ethanol-induced gastric damage in mice. Mice were pre-treated with saline, hemin (HO-1 inducer), biliverdin (HO-1 product), dimanganese decacarbonyl (DMDC, CO donor) or zinc protoporphyrin IX (ZnPP IX, HO-1 antagonist). Another group received soluble guanylate cyclase (sGC) inhibitor (ODQ) 30 min before hemin, biliverdin or DMDC. After 30 min, gastric damage was induced by ethanol… CONTINUE READING
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