Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.

@article{HirumaLima2001GastroprotectiveEO,
  title={Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.},
  author={Cl{\'e}lia Akiko Hiruma-Lima and Juliano de Souza Gracioso and Walber Toma and Ana Beatriz Albino de Almeida and A C B Paula and Davi S. B. Brasil and Adolfo Henrique Muller and Alba Regina Monteiro Souza Brito},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2001},
  volume={8 2},
  pages={94-100}
}
Aparisthmium cordatum (Juss.) Bail. (Euphorbiaceae), known in the State of Pará, Brazil as "ariquena queimosa", is a medium-sized tree which is native to the North Brazilian coastal region. Previous phytochemical studies of the bark of A. cordatum yielded a furan diterpenoid with a clerodane skeleton, called aparisthman. Recently, we reported the antiulcerogenic activity of trans-dehydrocrotonin (DHC), a furan diterpene isolated from Croton cajucara bark, in different ulcerogenic models in mice… CONTINUE READING