Gastroprotective effect and cytotoxicity of carnosic acid derivatives.

  title={Gastroprotective effect and cytotoxicity of carnosic acid derivatives.},
  author={Cristina Theoduloz and Mariano Walter Pertino and Jaime A Rodr{\'i}guez and Guillermo Schmeda-Hirschmann},
  journal={Planta medica},
  volume={77 9},
Carnosic acid (CA) is the main phenolic diterpene of rosemary (Rosmarinus officinalis L., Lamiaceae) and presents gastroprotective effect in vitro and in vivo. To determine structure-activity relationships, seventeen esters and ethers of CA were prepared, comprising aliphatic, aromatic, and heterocyclic compounds. The naturally occurring 12-O-methylcarnosic… CONTINUE READING