Gastroprotective Effect of Juanislamin on Ethanol-Induced Gastric Lesions in Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryl Groups in the Mechanism of Action

@article{SnchezMendoza2020GastroprotectiveEO,
  title={Gastroprotective Effect of Juanislamin on Ethanol-Induced Gastric Lesions in Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryl Groups in the Mechanism of Action},
  author={Mar{\'i}a Elena S{\'a}nchez-Mendoza and Yaraset L{\'o}pez-Lorenzo and Leticia Cruz-Antonio and Arturo Cruz-Oseguera and Jazm{\'i}n Garc{\'i}a-Machorro and Jes{\'u}s Arrieta},
  journal={Molecules},
  year={2020},
  volume={25}
}
Peptic ulcer disease, the most common gastrointestinal disorder, is currently treated with several types of drugs, but all have severe side effects. The aim of the present study was to evaluate the gastroprotective activity of juanislamin, isolated from Calea urticifolia, in a rat model of ethanol-induced gastric lesions. Thirty minutes after orally administering a given dose of juanislamin (from 1 to 30 mg/kg) or carbenoxolone (the reference drug, at 1–100 mg/kg) to rats, 1 mL of ethanol was… Expand
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