Gastroprotective Effect of Juanislamin on Ethanol-Induced Gastric Lesions in Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryl Groups in the Mechanism of Action

  title={Gastroprotective Effect of Juanislamin on Ethanol-Induced Gastric Lesions in Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryl Groups in the Mechanism of Action},
  author={Mar{\'i}a Elena S{\'a}nchez-Mendoza and Yaraset L{\'o}pez-Lorenzo and Leticia Cruz-Antonio and Arturo Cruz-Oseguera and Jazm{\'i}n Garc{\'i}a-Machorro and Jes{\'u}s Arrieta},
Peptic ulcer disease, the most common gastrointestinal disorder, is currently treated with several types of drugs, but all have severe side effects. The aim of the present study was to evaluate the gastroprotective activity of juanislamin, isolated from Calea urticifolia, in a rat model of ethanol-induced gastric lesions. Thirty minutes after orally administering a given dose of juanislamin (from 1 to 30 mg/kg) or carbenoxolone (the reference drug, at 1–100 mg/kg) to rats, 1 mL of ethanol was… Expand
1 Citations
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Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryls
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Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice.
OECC demonstrated significant gastroprotective activity associated with low toxicity, providing scientific evidences that C. rhamnifolioides have the potential for the development of new antiulcer drugs. Expand
Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.
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Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats
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Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress.
  • S. S Kwiecien, M. Pawlik, +4 authors S. Konturek
  • Chemistry, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2008
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Natural products in treatment of ulcerative colitis and peptic ulcer
The main concern of the current article is to introduce a safe drug (or more) of natural origin, to be used for the management of gastric ulcers without side effects. Expand