Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

@article{Zhivotova2009GastroprotectiveEO,
  title={Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs},
  author={E. Yu. Zhivotova and Matthew Fleishman and E. N. Sazonova and O. A. Lebed’ko and Sergey S Timoshin},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2009},
  volume={147},
  pages={441-443}
}
We studied the effect of dalargin and its analogue [Dala]2-leu-enkephalin on the gastric mucosa in indomethacin-receiving animals. Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues. Dalargin significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells, and reduced the degree of oxidative… CONTINUE READING