Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls

@article{SnchezMendoza2019GastroprotectionOC,
  title={Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls},
  author={Mar{\'i}a Elena S{\'a}nchez-Mendoza and Yaraset L{\'o}pez-Lorenzo and Leticia Cruz-Antonio and Audif{\'a}s-Salvador Matus-Meza and Yolanda S{\'a}nchez-Mendoza and Jes{\'u}s Arrieta},
  journal={Molecules},
  year={2019},
  volume={24}
}
Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the… Expand
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