Gastroprokinetic activity of nizatidine, a new H2-receptor antagonist, and its possible mechanism of action in dogs and rats.

@article{Ueki1993GastroprokineticAO,
  title={Gastroprokinetic activity of nizatidine, a new H2-receptor antagonist, and its possible mechanism of action in dogs and rats.},
  author={Shigeru Ueki and M Seiki and Tomoyuki Yoneta and H Aita and Korak Kanti Chaki and Yuuichi Hori and Hiroshi Morita and Eijiro Tagashira and Zen Itoh},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={264 1},
  pages={152-7}
}
We studied the anti-acetylcholinesterase (AChE) activity of a new H2-antagonist, nizatidine, in in vitro experiments and its gastroprokinetic action in the dog and rat in comparison with other H2-antagonists, neostigmine and cisapride. The IC50 of nizatidine for AChE was 6.7 x 10(-6) M, and this activity was reversible. The relative anti-AChE potency was in the following order: neostigmine > nizatidine > cimetidine >> famotidine. The inhibition of AChE by nizatidine was noncompetitive, with a… CONTINUE READING
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