Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial–mesenchymal transition in gastric cancers

@article{Yoon2011Gastrokine1F,
  title={Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial–mesenchymal transition in gastric cancers},
  author={Jung Hwan Yoon and Young Hwi Kang and Yoo Jin Choi and In Soo Park and Suk Woo Nam and Jung Young Lee and Yun Sil Lee and Won Sang Park},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2011},
  volume={137},
  pages={1697-1704}
}
Gastrokine 1 (GKN1) plays an important role in the gastric mucosal defense mechanism and also acts as a functional gastric tumor suppressor. The specific aim of this study was to determine the molecular mechanisms underlying GKN1 tumor suppressor activity in the progression of gastric cancers. We examined the effect of GKN1 on epithelial–mesenchymal transition (EMT) and cell migration in GKN1-transfected and recombinant GKN1-treated AGS gastric cancer cells using in vitro wound healing… CONTINUE READING
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