Gastrointestinal urease in man. I. Activity of mucosal urease.

@article{Aoyagi1966GastrointestinalUI,
  title={Gastrointestinal urease in man. I. Activity of mucosal urease.},
  author={T. Aoyagi and G. W. Engstrom and W. B. Evans and W. Summerskill},
  journal={Gut},
  year={1966},
  volume={7},
  pages={631 - 635}
}
The relationship postulated between hepatic coma and hyperammonaemia implicates the gastrointestinal tract as a major source of the excess ammonia in the peripheral blood of some patients with cirrhosis (Butt and Summerskill, 1961; Chalmers, 1960; Sherlock, Summerskill, White, and Phear, 1954). Conventional therapy, comprising protein restriction, antibiotics, and enemas, is directed toward eliminating from the gut nitrogenous material and bacteria (Butt and Summerskill, 1961; Chalmers, 1960… Expand
Gastrointestinal urease in man. II. Urea hydrolysis and ammonia absorption in upper and lower gut lumen and the effect of neomycin.
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A reinvestigation of the kinetics of the urease-catalyzed hydrolysis of urea in mice and the effect of antibiotics on urea breakdown in mice is shown. Expand
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Absorption and secretion by the colon.
Aries, V., Crowther, J. S., Drasar, B. S., Hill, M. J., and Williams, R. E. 0. (1969). Bacteria and the aetiology of cancer of the large bowel. Gut, 10, 334-335. Bircher, J., Mtiller, J., Guggenheim,Expand
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  • Alcoholism, clinical and experimental research
  • 1997
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Because antibiotics were shown over the last 4 decades to effectively eliminate gastric ammonia, they should be considered for the routine treatment of such chronic gastritis in the way they are now being used for ulcer therapy. Expand
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Outputs of ammonia by the colon studied by perfusion approximated the total produced in the cleansed organ and validate the rationale for management of hepatic coma, stress the efficacy of effective cleansing of the colon and describe a human model for assessment of therapy. Expand
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The now recognized "moonlighting" properties of these proteins have renewed interest in ureases for their biotechnological potential to improve plant defense against pests and as potential targets to ameliorate diseases due to pathogenic urease-producing microorganisms. Expand
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A systematic review of the role of H. pylori infection in the pathogenesis of (minimal) hepatic encephalopathy and the effect of eradication therapy on (M)HE found evidence from well-designed clinical studies is weak. Expand
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