Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation.

@article{Brunner2006GastrointestinalTR,
  title={Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation.},
  author={Martin Brunner and Sophie Ziegler and Andrea F. D. Di Stefano and Pejman Dehghanyar and Kurt Kletter and Manfred Tschurlovits and Roberto Barriales Villa and Roberta Bozzella and Giuseppe Celasco and Luigi Moro and Antonio Rusca and Robert Dudczak and Markus U. M{\"u}ller},
  journal={British journal of clinical pharmacology},
  year={2006},
  volume={61 1},
  pages={31-8}
}
AIMS The aims of the study were to: (1) evaluate the gastrointestinal transit, release and absorption of budesonide from tablets with a new multimatrix formulation (MMX) designed to release the drug throughout the whole colon, and (2) assess the influence of food on budesonide bioavailability. METHODS Two phase I studies, each comprising 12 healthy males, were performed. Gastrointestinal transit of (153)Sm-labelled tablets containing 9 mg budesonide was evaluated by means of pharmaco… CONTINUE READING

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