Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid

  title={Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid},
  author={D. M. Storey and A S Lee and Francis R. J. Bornet and Fred Brouns},
  journal={European Journal of Clinical Nutrition},
Objectives:To determine and compare the gastrointestinal (GI) responses of young adults following consumption of 45 g sucrose, 20, 35 and 50 g xylitol or erythritol given as a single oral, bolus dose in a liquid.Design:The study was a randomized, double-blind, placebo-controlled study.Subjects:Seventy healthy adult volunteers aged 18–24 years were recruited from the student population of the University of Salford. Sixty-four subjects completed the study.Interventions:Subjects consumed at home… 
Gastrointestinal tolerance of erythritol-containing beverage in young children: a double-blind, randomised controlled trial
Rapid ingestion of up to and including 15 g (6% w/v) of erythritol in a beverage in between meals by young children aged 4–6 years was well tolerated and children appeared not to be more sensitive to the GI effects of ersatz medicine than published for adults on a g/kg bw basis.
Gastrointestinal Tolerance of D-Allulose in Healthy and Young Adults. A Non-Randomized Controlled Trial
A GI tolerance test for D-allulose was performed in order to establish its daily acceptable intake level and suggest a maximum single dose and maximum total daily intake of D-Allulose of 0.4 g/kg·BW and 0.9 g/ kg·BW, respectively.
Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects.
With the increasing prevalence of obesity and a possible association with increasing sucrose consumption, nonnutritive sweeteners are gaining popularity. Given that some studies indicate that
Health effects of erythritol
It is concluded that erythritol could be of great importance and could be considered to be the preferred sugar substitute for a rapidly growing population of people with diabetes or pre-diabetes to reduce their risk of developing diabetic complications.
Gastrointestinal Effects of Low-Digestible Carbohydrates
A review of published studies reporting gastrointestinal effects of low-digestible carbohydrates evaluated published human feeding studies of fifteen LDCs for associations between gastrointestinal effects and levels of LDC intake, and presents recommendations for LDC consumption and further research.
Acute and sub-chronic oral toxicity studies of erythritol in Beagle dogs.
Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review
The current review thoroughly analyzes the anti-diabetic and antihyperglycemic effects as well as other metabolic effects of xylitol and erythritol using articles published in PubMed since the 1960s, containing research done on experimental animals and humans.
Erythritol Functional Roles in Oral-Systemic Health
Emerging evidence shows that erythritol can play a number of functional roles to actively support maintenance of oral and systemic health.
Erythritol Is More Effective Than Xylitol and Sorbitol in Managing Oral Health Endpoints
Evidence is provided demonstrating better efficacy of erythritol compared to sorbitol and xylitol to maintain and improve oral health.
Oral and Systemic Effects of Xylitol Consumption
Any systemic benefits of xylitol intake must be weighed in consideration with the well-established adverse gastrointestinal consequences, and the contribution ofxylitol to gut dysbiosis that may affect systemic immunity warrants further research.


Tolerance to subchronic, high-dose ingestion of erythritol in human volunteers.
The results of the present study demonstrate that the repeated ingestion of erythritol at daily doses of 1 g/kg body wt was well tolerated by humans.
Laxative threshold of sugar alcohol erythritol in human subjects
Gastrointestinal response and plasma and urine determinations in human subjects given erythritol.
It is demonstrated that ingestion of erythritol at doses of up to 0.8 g/kg body wt does not alter plasma or urine osmolarity or electrolyte balance and is well tolerated by the digestive tract.
Comparative gastrointestinal tolerance of sucrose, lactitol, or D-tagatose in chocolate.
It is demonstrated that a 20-g dose of D-tagatose is tolerated well in comparison to lactitol, and is associated with a significant increase in the frequency of passing feces, or in the number of subjects passing watery feces, in a double-blind, controlled crossover study.
The comparative gastrointestinal response of young children to the ingestion of 25 g sweets containing sucrose or isomalt
For the majority of children in the present study, 25 g isomalt-containing sweets represents an acceptable level of consumption, although some children are sensitive to the effects of isomALT ingestion.
Effects of oral administration of erythritol on patients with diabetes.
The single dose study suggests that erythritol exerts no significant effects on the metabolism of diabetic patients and two-week daily administration of erystritol had no adverse effect on blood glucose control.
Oral xylitol in American adults
[Clinical tolerance, intestinal absorption, and energy value of four sugar alcohols taken on an empty stomach].
Bacterial digestion of the sugar alcohols reaching the colon was complete, and did not affect healthy volunteers' clinical tolerance and energy value, according to their respective rates of digestion in the small intestine and the colon.
Metabolism of erythritol in humans: Comparison with glucose and lactitol
It is concluded that erythritol is a substrate that is readily absorbed, and undergoes no metabolism by the host, and if part of it escapes absorption, it is not metabolized by faecal flora.
Tolerance to low-digestible carbohydrates: symptomatology and methods.
There is an important intersubject variability in the tolerance to LDCs because of differences in absorption capacity, motility pattern, colonic response and intestinal sensitivity.