Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment.

@article{Hawkey1998GastrointestinalTO,
  title={Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment.},
  author={Christopher John Hawkey and Andr{\'e} Kahan and Klaus Steinbrueck and Cayetano Alegre and Elisabeth Baumelou and Bernard B{\'e}gaud and Jan Dequeker and Heikki A Isom{\"a}ki and Geoffrey Littlejohn and Jochen Mau and Sotirios Papazoglou},
  journal={British journal of rheumatology},
  year={1998},
  volume={37 9},
  pages={937-45}
}
Although widely used, non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a high incidence of gastrointestinal (GI) side-effects. Inhibition of the cyclooxygenase (COX) enzyme is the basis for both the efficacy and toxicity of NSAIDs. The discovery of two COX isoforms, constitutive COX-1 and inducible COX-2, has led to the hypothesis that selective inhibition of COX-2 will minimize the potential for GI toxicity without compromising efficacy. The Meloxicam Large-scale… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

: influence on arachidonic acid metabolism . Gothoskar , UAE ; Andreas Gotsopoulos , Greece ; In vitro findings — part I

  • G Engelhardt, R Bögel, C Schnitzler, R Utzmann, Shekhar Meloxicam
  • Biochem Pharmacol
  • 1996

Risk of upper gastrointesRheumatol 1996;35:68–77. tinal bleeding and perforation associated with indivi22

  • LA Garcı́a Rodrı́guez, H. Jick
  • Br J Rheumatol
  • 1996
1 Excerpt

Worldwide clinical safety experience withPiroxicam . A reappraisal of its pharmacology and therapeutic e ffi cacy

  • RN Brogden, RC Heel, TM Speight, GS Avery, RF Willkens
  • Br J Rheumatol
  • 1996
1 Excerpt

Inhibition of prostaglandin synthesis as a mechanism of action of aspirinlike drugs . Nature ( New cise

  • Vane
  • Lancet
  • 1994

Meloxicam indual non - steroidal anti - inflammatory drugs

  • J Hosie, M Distel, E Bluhmki
  • Lancet osteoarthritis : a 6 - month , double…
  • 1994

Risks of HAWKEY ET AL

  • W Xie, JG Chipman, +4 authors P Wainwright
  • Epidemiology
  • 1992

Similar Papers

Loading similar papers…