Gastrointestinal stromal tumours.

  title={Gastrointestinal stromal tumours.},
  author={Elizabeth M. Connolly and Eoin Gaffney and John Vincent Reynolds},
  journal={The British journal of surgery},
  volume={90 10},
BACKGROUND Gastrointestinal stromal tumours (GISTs), previously classified as benign or malignant smooth muscle tumours, are the most common mesenchymal tumours of the gastrointestinal tract. GISTs express a growth factor receptor with tyrosine kinase activity, termed KIT. Mutations of KIT are common in malignant GISTs and lead to constitutional activation of tyrosine kinase function, which causes cellular proliferation and resistance to apoptosis. GISTs are notoriously unresponsive to… CONTINUE READING