Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases.

@article{Miettinen2006GastrointestinalST,
  title={Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases.},
  author={Markku M. Miettinen and John F. Fetsch and Leslie H. Sobin and Jerzy Lasota},
  journal={The American journal of surgical pathology},
  year={2006},
  volume={30 1},
  pages={
          90-6
        }
}
Gastrointestinal stromal tumors (GISTs), the specific KIT- or PDFGRA-signaling driven mesenchymal tumors, most commonly occur sporadically, but there seems to be some increased tendency for these tumors to develop in patients with neurofibromatosis 1 (NF1). The clinicopathologic profile, KIT, and PDGFRA mutation status and long-term prognosis of patients with GIST in NF1 are incompletely characterized. In this study, we analyzed 45 patients who had NF1 and GIST. There were 26 females and 19… CONTINUE READING
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